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Challenges in solving structures from radiation-damaged tomograms of protein nanocrystals assessed by simulation

Structure-determination methods are needed to resolve the atomic details that underlie protein function. X-ray crystallography has provided most of our knowledge of protein structure, but is constrained by the need for large, well ordered crystals and the loss of phase information. The rapidly devel...

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Detalles Bibliográficos
Autores principales: Peck, Ariana, Yao, Qing, Brewster, Aaron S., Zwart, Petrus H., Heumann, John M., Sauter, Nicholas K., Jensen, Grant J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098477/
https://www.ncbi.nlm.nih.gov/pubmed/33950014
http://dx.doi.org/10.1107/S2059798321002369