Immune modulation attenuates infantile neuronal ceroid lipofuscinosis in mice before and after disease onset

Targeting neuroinflammation in models for infantile and juvenile forms of neuronal ceroid lipofuscinosis (NCL, CLN disease) with the clinically established immunomodulators fingolimod and teriflunomide significantly attenuates the neurodegenerative phenotype when applied preventively, i.e. before th...

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Detalles Bibliográficos
Autores principales: Groh, Janos, Berve, Kristina, Martini, Rudolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098642/
https://www.ncbi.nlm.nih.gov/pubmed/33977263
http://dx.doi.org/10.1093/braincomms/fcab047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098642/
https://www.ncbi.nlm.nih.gov/pubmed/33977263
http://dx.doi.org/10.1093/braincomms/fcab047

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