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Immune modulation attenuates infantile neuronal ceroid lipofuscinosis in mice before and after disease onset
Targeting neuroinflammation in models for infantile and juvenile forms of neuronal ceroid lipofuscinosis (NCL, CLN disease) with the clinically established immunomodulators fingolimod and teriflunomide significantly attenuates the neurodegenerative phenotype when applied preventively, i.e. before th...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098642/ https://www.ncbi.nlm.nih.gov/pubmed/33977263 http://dx.doi.org/10.1093/braincomms/fcab047 |