Molecular mechanism of secreted amyloid-β precursor protein in binding and modulating GABA(B)R1a

A recent phenomenal study discovered that the extension domain of secreted amyloid-β precursor protein (sAPP) can bind to the intrinsically disordered sushi 1 domain of the γ-aminobutyric acid type B receptor subunit 1a (GABA(B)R1a) and modulate its synaptic transmission. The work provided an import...

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Detalles Bibliográficos
Autores principales: Feng, Mei, Song, Yi, Chen, Serena H., Zhang, Yuanzhao, Zhou, Ruhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098695/
https://www.ncbi.nlm.nih.gov/pubmed/33996007
http://dx.doi.org/10.1039/d0sc06946a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098695/
https://www.ncbi.nlm.nih.gov/pubmed/33996007
http://dx.doi.org/10.1039/d0sc06946a

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