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Revised subunit order of mammalian septin complexes explains their in vitro polymerization properties

Septins are conserved GTP-binding cytoskeletal proteins that polymerize into filaments by end-to-end joining of hetero-oligomeric complexes. In human cells, both hexamers and octamers exist, and crystallography studies predicted the order of the hexamers to be SEPT7-SEPT6-SEPT2-SEPT2-SEPT6-SEPT7, wh...

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Detalles Bibliográficos
Autores principales: Soroor, Forooz, Kim, Moshe S., Palander, Oliva, Balachandran, Yadu, Collins, Richard F., Benlekbir, Samir, Rubinstein, John L., Trimble, William S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098831/
https://www.ncbi.nlm.nih.gov/pubmed/33263440
http://dx.doi.org/10.1091/mbc.E20-06-0398