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Machine-learning a virus assembly fitness landscape

Realistic evolutionary fitness landscapes are notoriously difficult to construct. A recent cutting-edge model of virus assembly consists of a dodecahedral capsid with 12 corresponding packaging signals in three affinity bands. This whole genome/phenotype space consisting of 3(12) genomes has been ex...

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Detalles Bibliográficos
Autores principales: Dechant, Pierre-Philippe, He, Yang-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099058/
https://www.ncbi.nlm.nih.gov/pubmed/33951035
http://dx.doi.org/10.1371/journal.pone.0250227