Clinical evaluation of BCL-2/X(L) levels pre- and post- HER2-targeted therapy

Our previous pre-clinical work defined BCL-2 induction as a critical component of the adaptive response to lapatinib-mediated inhibition of HER2. To determine whether a similar BCL-2 upregulation occurs in lapatinib-treated patients, we evaluated gene expression within tumor biopsies, collected befo...

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Detalles Bibliográficos
Autores principales: Zoeller, Jason J., Press, Michael F., Selfors, Laura M., Dering, Judy, Slamon, Dennis J., Hurvitz, Sara A., Brugge, Joan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099090/
https://www.ncbi.nlm.nih.gov/pubmed/33951110
http://dx.doi.org/10.1371/journal.pone.0251163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099090/
https://www.ncbi.nlm.nih.gov/pubmed/33951110
http://dx.doi.org/10.1371/journal.pone.0251163

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