The Possible Non-Mutational Causes of FVIII Deficiency: Non-Coding RNAs and Acquired Hemophilia A

Hemophilia type A (HA) is the most common type of blood coagulation disorder. While the vast majority of cases are inherited and caused by mutations in the F8 gene, recent data raises new questions regarding the non-heritability of this disease, as well as how other molecular mechanisms might lead t...

Descripción completa

Detalles Bibliográficos
Autores principales: Zimta, Alina-Andreea, Hotea, Ionut, Brinza, Melen, Blag, Cristina, Iluta, Sabina, Constantinescu, Catalin, Bashimov, Atamyrat, Marchis-Hund, Elisabeth-Antonia, Coudsy, Alexandra, Muller-Mohnssen, Laetitia, Dirzu, Noemi, Gulei, Diana, Dima, Delia, Serban, Margit, Coriu, Daniel, Tomuleasa, Ciprian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099106/
https://www.ncbi.nlm.nih.gov/pubmed/33968959
http://dx.doi.org/10.3389/fmed.2021.654197
_version_ 1783688536224956416
author Zimta, Alina-Andreea
Hotea, Ionut
Brinza, Melen
Blag, Cristina
Iluta, Sabina
Constantinescu, Catalin
Bashimov, Atamyrat
Marchis-Hund, Elisabeth-Antonia
Coudsy, Alexandra
Muller-Mohnssen, Laetitia
Dirzu, Noemi
Gulei, Diana
Dima, Delia
Serban, Margit
Coriu, Daniel
Tomuleasa, Ciprian
author_facet Zimta, Alina-Andreea
Hotea, Ionut
Brinza, Melen
Blag, Cristina
Iluta, Sabina
Constantinescu, Catalin
Bashimov, Atamyrat
Marchis-Hund, Elisabeth-Antonia
Coudsy, Alexandra
Muller-Mohnssen, Laetitia
Dirzu, Noemi
Gulei, Diana
Dima, Delia
Serban, Margit
Coriu, Daniel
Tomuleasa, Ciprian
author_sort Zimta, Alina-Andreea
collection PubMed
description Hemophilia type A (HA) is the most common type of blood coagulation disorder. While the vast majority of cases are inherited and caused by mutations in the F8 gene, recent data raises new questions regarding the non-heritability of this disease, as well as how other molecular mechanisms might lead to the development of HA or increase the severity of the disease. Some data suggest that miRNAs may affect the severity of HA, but for some patients, miRNA-based interference might cause HA, in the absence of an F8 mutation. A mechanism in HA installation that is also worth investigating and which could be identified in the future is the epigenetic silencing of the F8 gene that might be only temporarily. Acquired HA is increasingly reported and as more cases are identified, the description of the disease might become challenging, as cases without FVIII autoantibodies might be identified.
format Online
Article
Text
id pubmed-8099106
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-80991062021-05-06 The Possible Non-Mutational Causes of FVIII Deficiency: Non-Coding RNAs and Acquired Hemophilia A Zimta, Alina-Andreea Hotea, Ionut Brinza, Melen Blag, Cristina Iluta, Sabina Constantinescu, Catalin Bashimov, Atamyrat Marchis-Hund, Elisabeth-Antonia Coudsy, Alexandra Muller-Mohnssen, Laetitia Dirzu, Noemi Gulei, Diana Dima, Delia Serban, Margit Coriu, Daniel Tomuleasa, Ciprian Front Med (Lausanne) Medicine Hemophilia type A (HA) is the most common type of blood coagulation disorder. While the vast majority of cases are inherited and caused by mutations in the F8 gene, recent data raises new questions regarding the non-heritability of this disease, as well as how other molecular mechanisms might lead to the development of HA or increase the severity of the disease. Some data suggest that miRNAs may affect the severity of HA, but for some patients, miRNA-based interference might cause HA, in the absence of an F8 mutation. A mechanism in HA installation that is also worth investigating and which could be identified in the future is the epigenetic silencing of the F8 gene that might be only temporarily. Acquired HA is increasingly reported and as more cases are identified, the description of the disease might become challenging, as cases without FVIII autoantibodies might be identified. Frontiers Media S.A. 2021-04-15 /pmc/articles/PMC8099106/ /pubmed/33968959 http://dx.doi.org/10.3389/fmed.2021.654197 Text en Copyright © 2021 Zimta, Hotea, Brinza, Blag, Iluta, Constantinescu, Bashimov, Marchis-Hund, Coudsy, Muller-Mohnssen, Dirzu, Gulei, Dima, Serban, Coriu and Tomuleasa. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Zimta, Alina-Andreea
Hotea, Ionut
Brinza, Melen
Blag, Cristina
Iluta, Sabina
Constantinescu, Catalin
Bashimov, Atamyrat
Marchis-Hund, Elisabeth-Antonia
Coudsy, Alexandra
Muller-Mohnssen, Laetitia
Dirzu, Noemi
Gulei, Diana
Dima, Delia
Serban, Margit
Coriu, Daniel
Tomuleasa, Ciprian
The Possible Non-Mutational Causes of FVIII Deficiency: Non-Coding RNAs and Acquired Hemophilia A
title The Possible Non-Mutational Causes of FVIII Deficiency: Non-Coding RNAs and Acquired Hemophilia A
title_full The Possible Non-Mutational Causes of FVIII Deficiency: Non-Coding RNAs and Acquired Hemophilia A
title_fullStr The Possible Non-Mutational Causes of FVIII Deficiency: Non-Coding RNAs and Acquired Hemophilia A
title_full_unstemmed The Possible Non-Mutational Causes of FVIII Deficiency: Non-Coding RNAs and Acquired Hemophilia A
title_short The Possible Non-Mutational Causes of FVIII Deficiency: Non-Coding RNAs and Acquired Hemophilia A
title_sort possible non-mutational causes of fviii deficiency: non-coding rnas and acquired hemophilia a
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099106/
https://www.ncbi.nlm.nih.gov/pubmed/33968959
http://dx.doi.org/10.3389/fmed.2021.654197
work_keys_str_mv AT zimtaalinaandreea thepossiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT hoteaionut thepossiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT brinzamelen thepossiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT blagcristina thepossiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT ilutasabina thepossiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT constantinescucatalin thepossiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT bashimovatamyrat thepossiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT marchishundelisabethantonia thepossiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT coudsyalexandra thepossiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT mullermohnssenlaetitia thepossiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT dirzunoemi thepossiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT guleidiana thepossiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT dimadelia thepossiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT serbanmargit thepossiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT coriudaniel thepossiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT tomuleasaciprian thepossiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT zimtaalinaandreea possiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT hoteaionut possiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT brinzamelen possiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT blagcristina possiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT ilutasabina possiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT constantinescucatalin possiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT bashimovatamyrat possiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT marchishundelisabethantonia possiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT coudsyalexandra possiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT mullermohnssenlaetitia possiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT dirzunoemi possiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT guleidiana possiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT dimadelia possiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT serbanmargit possiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT coriudaniel possiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa
AT tomuleasaciprian possiblenonmutationalcausesoffviiideficiencynoncodingrnasandacquiredhemophiliaa