The Possible Non-Mutational Causes of FVIII Deficiency: Non-Coding RNAs and Acquired Hemophilia A
Hemophilia type A (HA) is the most common type of blood coagulation disorder. While the vast majority of cases are inherited and caused by mutations in the F8 gene, recent data raises new questions regarding the non-heritability of this disease, as well as how other molecular mechanisms might lead t...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099106/ https://www.ncbi.nlm.nih.gov/pubmed/33968959 http://dx.doi.org/10.3389/fmed.2021.654197 |
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author | Zimta, Alina-Andreea Hotea, Ionut Brinza, Melen Blag, Cristina Iluta, Sabina Constantinescu, Catalin Bashimov, Atamyrat Marchis-Hund, Elisabeth-Antonia Coudsy, Alexandra Muller-Mohnssen, Laetitia Dirzu, Noemi Gulei, Diana Dima, Delia Serban, Margit Coriu, Daniel Tomuleasa, Ciprian |
author_facet | Zimta, Alina-Andreea Hotea, Ionut Brinza, Melen Blag, Cristina Iluta, Sabina Constantinescu, Catalin Bashimov, Atamyrat Marchis-Hund, Elisabeth-Antonia Coudsy, Alexandra Muller-Mohnssen, Laetitia Dirzu, Noemi Gulei, Diana Dima, Delia Serban, Margit Coriu, Daniel Tomuleasa, Ciprian |
author_sort | Zimta, Alina-Andreea |
collection | PubMed |
description | Hemophilia type A (HA) is the most common type of blood coagulation disorder. While the vast majority of cases are inherited and caused by mutations in the F8 gene, recent data raises new questions regarding the non-heritability of this disease, as well as how other molecular mechanisms might lead to the development of HA or increase the severity of the disease. Some data suggest that miRNAs may affect the severity of HA, but for some patients, miRNA-based interference might cause HA, in the absence of an F8 mutation. A mechanism in HA installation that is also worth investigating and which could be identified in the future is the epigenetic silencing of the F8 gene that might be only temporarily. Acquired HA is increasingly reported and as more cases are identified, the description of the disease might become challenging, as cases without FVIII autoantibodies might be identified. |
format | Online Article Text |
id | pubmed-8099106 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80991062021-05-06 The Possible Non-Mutational Causes of FVIII Deficiency: Non-Coding RNAs and Acquired Hemophilia A Zimta, Alina-Andreea Hotea, Ionut Brinza, Melen Blag, Cristina Iluta, Sabina Constantinescu, Catalin Bashimov, Atamyrat Marchis-Hund, Elisabeth-Antonia Coudsy, Alexandra Muller-Mohnssen, Laetitia Dirzu, Noemi Gulei, Diana Dima, Delia Serban, Margit Coriu, Daniel Tomuleasa, Ciprian Front Med (Lausanne) Medicine Hemophilia type A (HA) is the most common type of blood coagulation disorder. While the vast majority of cases are inherited and caused by mutations in the F8 gene, recent data raises new questions regarding the non-heritability of this disease, as well as how other molecular mechanisms might lead to the development of HA or increase the severity of the disease. Some data suggest that miRNAs may affect the severity of HA, but for some patients, miRNA-based interference might cause HA, in the absence of an F8 mutation. A mechanism in HA installation that is also worth investigating and which could be identified in the future is the epigenetic silencing of the F8 gene that might be only temporarily. Acquired HA is increasingly reported and as more cases are identified, the description of the disease might become challenging, as cases without FVIII autoantibodies might be identified. Frontiers Media S.A. 2021-04-15 /pmc/articles/PMC8099106/ /pubmed/33968959 http://dx.doi.org/10.3389/fmed.2021.654197 Text en Copyright © 2021 Zimta, Hotea, Brinza, Blag, Iluta, Constantinescu, Bashimov, Marchis-Hund, Coudsy, Muller-Mohnssen, Dirzu, Gulei, Dima, Serban, Coriu and Tomuleasa. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Zimta, Alina-Andreea Hotea, Ionut Brinza, Melen Blag, Cristina Iluta, Sabina Constantinescu, Catalin Bashimov, Atamyrat Marchis-Hund, Elisabeth-Antonia Coudsy, Alexandra Muller-Mohnssen, Laetitia Dirzu, Noemi Gulei, Diana Dima, Delia Serban, Margit Coriu, Daniel Tomuleasa, Ciprian The Possible Non-Mutational Causes of FVIII Deficiency: Non-Coding RNAs and Acquired Hemophilia A |
title | The Possible Non-Mutational Causes of FVIII Deficiency: Non-Coding RNAs and Acquired Hemophilia A |
title_full | The Possible Non-Mutational Causes of FVIII Deficiency: Non-Coding RNAs and Acquired Hemophilia A |
title_fullStr | The Possible Non-Mutational Causes of FVIII Deficiency: Non-Coding RNAs and Acquired Hemophilia A |
title_full_unstemmed | The Possible Non-Mutational Causes of FVIII Deficiency: Non-Coding RNAs and Acquired Hemophilia A |
title_short | The Possible Non-Mutational Causes of FVIII Deficiency: Non-Coding RNAs and Acquired Hemophilia A |
title_sort | possible non-mutational causes of fviii deficiency: non-coding rnas and acquired hemophilia a |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099106/ https://www.ncbi.nlm.nih.gov/pubmed/33968959 http://dx.doi.org/10.3389/fmed.2021.654197 |
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