Cargando…

MicroRNA-499 serves as a sensitizer for lung cancer cells to radiotherapy by inhibition of CK2α-mediated phosphorylation of p65

The present study aimed to define the tumor-suppressive role of microRNA-499 (miR-499) in lung cancer cells and its underlying mechanism. First, qRT-PCR analysis revealed poor expression of miR-499 in clinical samples and cell lines of lung cancer. Next, we performed loss- and gain-of-function exper...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, Yu-Shui, Shi, Bo-Wen, Lu, Hai-Min, Xie, Peng-Fei, Xin, Rui, Wu, Zhi-Jun, Shi, Yi, Yin, Yu-Zhen, Hou, Li-Kun, Jia, Cheng-You, Wu, Wei, Lv, Zhong-Wei, Yu, Fei, Wang, Gao-Ren, Liu, Ji-Bin, Jiang, Geng-Xi, Fu, Da
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099482/ https://www.ncbi.nlm.nih.gov/pubmed/33997273 http://dx.doi.org/10.1016/j.omto.2021.03.016

Ejemplares similares

Mammalian FMRP S499 Is Phosphorylated by CK2 and Promotes Secondary Phosphorylation of FMRP
por: Bartley, Christopher M., et al.
Publicado: (2016)

Cyclic stretching boosts microRNA‐499 to regulate Bcl‐2 via microRNA‐208a in atrial fibroblasts
por: Chua, Su‐Kiat, et al.
Publicado: (2021)

Regulation of cardiac CACNB2 by microRNA-499: Potential role in atrial fibrillation
por: Ling, Tian-You, et al.
Publicado: (2017)

CK2 Phosphorylates Sec31 and Regulates ER-To-Golgi Trafficking
por: Koreishi, Mayuko, et al.
Publicado: (2013)

FMRP S499 Is Phosphorylated Independent of mTORC1-S6K1 Activity
por: Bartley, Christopher M., et al.
Publicado: (2014)

Comparison of Equivalence between Two Commercially Available S499-Phosphorylated FMRP Antibodies in Mice
por: Reynolds, Conner D., et al.
Publicado: (2015)

Circulating MicroRNA-499 as a Diagnostic Biomarker for Acute Myocardial Infarction: A Meta-analysis
por: Zhao, Jingyi, et al.
Publicado: (2019)

MicroRNA-499 rs3746444 polymorphism in Egyptian children with biliary atresia
por: Gawish, Eman, et al.
Publicado: (2020)

Regulation of CK2 by Phosphorylation and O-GlcNAcylation Revealed by Semisynthesis
por: Tarrant, Mary Katherine, et al.
Publicado: (2012)

The altered expression profile of microRNAs in cardiopulmonary bypass canine models and the effects of mir-499 on myocardial ischemic reperfusion injury
por: Qin, Han, et al.
Publicado: (2013)

Protein kinase CK2α catalytic subunit is overexpressed and serves as an unfavorable prognostic marker in primary hepatocellular carcinoma
por: Zhang, Hong-Xia, et al.
Publicado: (2015)

Poster Sessions 499–563
Publicado: (2001)

Enhanced Efficacy of Doxorubicin by microRNA-499-Mediated Improvement of Tumor Blood Flow
por: Okamoto, Ayaka, et al.
Publicado: (2016)

Genetic and functional analyses implicate microRNA 499A in bipolar disorder development
por: Tielke, Aileen, et al.
Publicado: (2022)

CK2 promotes jasmonic acid signaling response by phosphorylating MYC2 in Arabidopsis
por: Zhu, Jiang, et al.
Publicado: (2022)

Distinct Roles of MicroRNA-1 and -499 in Ventricular Specification and Functional Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes
por: Fu, Ji-Dong, et al.
Publicado: (2011)

Loss of ATF3 Promotes Hormone-induced Prostate Carcinogenesis and the Emergence of CK5(+)CK8(+) Epithelial Cells
por: Wang, Ziyan, et al.
Publicado: (2015)

499 Visiting Scholars in Times of Pandemic
por: Moussatche, Patricia, et al.
Publicado: (2022)

Down-Regulated CK8 Expression in Human Intervertebral Disc Degeneration
por: Sun, Zhen, et al.
Publicado: (2013)

The Expression and Effection of MicroRNA-499a in High-Tobacco Exposed Head and Neck Squamous Cell Carcinoma: A Bioinformatic Analysis
por: Gong, Shi-Qi, et al.
Publicado: (2019)

MicroRNA-499 Suppresses the Growth of Hepatocellular Carcinoma by Downregulating Astrocyte Elevated Gene-1
por: Wang, Jing, et al.
Publicado: (2020)

Elevated miR-499 Levels Blunt the Cardiac Stress Response
por: Shieh, Joseph T. C., et al.
Publicado: (2011)

Mechanical Stretch Inhibits MicroRNA499 via p53 to Regulate Calcineurin-A Expression in Rat Cardiomyocytes
por: Chua, Su-Kiat, et al.
Publicado: (2016)

A polymorphism rs3746444 within the pre‐miR‐499 alters the maturation of miR‐499‐5p and its antiapoptotic function
por: Ding, Wei, et al.
Publicado: (2018)

MiR-499a prevents astrocytes mediated inflammation in ischemic stroke by targeting PTEN
por: Guan, Xiaoxiang, et al.
Publicado: (2021)

Lymphotoxins Serve as a Novel Orchestrator in T1D Pathogenesis
por: Liu, Shi-Wei, et al.
Publicado: (2022)

Invasive Lobular Carcinomas Do Not Express Basal Cytokeratin Markers CK5/6, CK14 and CK17
por: Khilko, Natalya, et al.
Publicado: (2010)

The First Homozygote Mutation c.499G>T (Asp167Tyr) in the RPE65 Gene Encoding Retinoid Isomerohydrolase Causing Retinal Dystrophy
por: Bjeloš, Mirjana, et al.
Publicado: (2022)

Macro-CK and CK-BB Contributing to Sham CK-MB Elevation
por: Wada, Yuki, et al.
Publicado: (2017)

Development of the CK‐MB‐1 trastuzumab‐resistant HER2‐positive breast cancer cell line and xenograft animal models
por: Chung, Wei‐Pang, et al.
Publicado: (2021)

Evolution of the myosin heavy chain gene MYH14 and its intronic microRNA miR-499: muscle-specific miR-499 expression persists in the absence of the ancestral host gene
por: Bhuiyan, Sharmin Siddique, et al.
Publicado: (2013)

SAT-499 Denosumab for Treatment of Hypercalcemia in Myelofibrosis
por: Wong, Beatrice, et al.
Publicado: (2019)

SLC52A3 expression is activated by NF-κB p65/Rel-B and serves as a prognostic biomarker in esophageal cancer
por: Long, Lin, et al.
Publicado: (2018)

The Association between Two MicroRNA Variants (miR-499, miR-149) and Gastrointestinal Cancer Risk: A Meta-Analysis
por: Li, Li, et al.
Publicado: (2013)

Correction: Mechanical Stretch Inhibits MicroRNA499 via p53 to Regulate Calcineurin-A Expression in Rat Cardiomyocytes
por: Chual, Su-Kiat, et al.
Publicado: (2016)

RP1 Is a Phosphorylation Target of CK2 and Is Involved in Cell Adhesion
por: Stenner, Frank, et al.
Publicado: (2013)

CK1δ Kinase Activity Is Modulated by Chk1-Mediated Phosphorylation
por: Bischof, Joachim, et al.
Publicado: (2013)

The Phosphorylation of PDX-1 by Protein Kinase CK2 Is Crucial for Its Stability
por: Klein, Sabrina, et al.
Publicado: (2016)

Comprehensive Characterization of CK1δ-Mediated Tau Phosphorylation in Alzheimer’s Disease
por: Roth, Aileen, et al.
Publicado: (2022)

Prognostic implications of decreased microRNA-101-3p expression in patients with non-small cell lung cancer
por: Lu, Hai-Min, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_4l5dvmiddh0havpto1oh9i02np