Dickkopf-2 regulates the stem cell marker LGR5 in colorectal cancer via HNF4α1

Enhanced stemness in colorectal cancer has been reported and it contributes to aggressive progression, but the underlying mechanisms remain unclear. Here we report a Wnt ligand, Dickkopf-2 (DKK2) is essential for developing colorectal cancer stemness. Genetic depletion of DKK2 in intestinal epitheli...

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Detalles Bibliográficos
Autores principales: Shin, Jae Hun, Jeong, Jaekwang, Choi, Jungmin, Lim, Jaechul, Dinesh, Ravi K., Braverman, Jonathan, Hong, Jun Young, Maher, Stephen E., Amezcua Vesely, Maria C., Kim, WonJu, Koo, Ja-Hyun, Tang, Wenwen, Wu, Dianqing, Blackburn, Holly N., Xicola, Rosa M., Llor, Xavier, Yilmaz, Omer, Choi, Je-Min, Bothwell, Alfred L.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099562/
https://www.ncbi.nlm.nih.gov/pubmed/33997693
http://dx.doi.org/10.1016/j.isci.2021.102411

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099562/
https://www.ncbi.nlm.nih.gov/pubmed/33997693
http://dx.doi.org/10.1016/j.isci.2021.102411

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