Cargando…
Forebrain-specific deficiency of the GTPase CRAG/Centaurin-γ3 leads to immature dentate gyri and hyperactivity in mice
Mouse models of various neuropsychiatric disorders, such as schizophrenia, often display an immature dentate gyrus, characterized by increased numbers of immature neurons and neuronal progenitors and a dearth of mature neurons. We previously demonstrated that the CRMP5-associated GTPase (CRAG), a sh...
Autores principales: | Nagashima, Shun, Ito, Naoki, Kobayashi, Reiki, Shiiba, Isshin, Shimura, Hiroki, Fukuda, Toshifumi, Hagihara, Hideo, Miyakawa, Tsuyoshi, Inatome, Ryoko, Yanagi, Shigeru |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099661/ https://www.ncbi.nlm.nih.gov/pubmed/33811862 http://dx.doi.org/10.1016/j.jbc.2021.100620 |
Ejemplares similares
-
Critical role of CRAG, a splicing variant of centaurin-γ3/AGAP3, in ELK1-dependent SRF activation at PML bodies
por: Nagashima, Shun, et al.
Publicado: (2019) -
A novel GTPase, CRAG, mediates promyelocytic leukemia protein–associated nuclear body formation and degradation of expanded polyglutamine protein
por: Qin, Qingyu, et al.
Publicado: (2006) -
Forebrain-specific conditional calcineurin deficiency induces dentate gyrus immaturity and hyper-dopaminergic signaling in mice
por: Hagihara, Hideo, et al.
Publicado: (2022) -
MITOL prevents ER stress‐induced apoptosis by IRE1α ubiquitylation at ER–mitochondria contact sites
por: Takeda, Keisuke, et al.
Publicado: (2019) -
Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation
por: Takeda, Keisuke, et al.
Publicado: (2021)