Integrated chromatin and transcriptomic profiling of patient-derived colon cancer organoids identifies personalized drug targets to overcome oxaliplatin resistance

Colorectal cancer is a leading cause of cancer deaths. Most colorectal cancer patients eventually develop chemoresistance to the current standard-of-care therapies. Here, we used patient-derived colorectal cancer organoids to demonstrate that resistant tumor cells undergo significant chromatin chang...

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Detalles Bibliográficos
Autores principales: Tung, Kuei-Ling, Chen, Kai-Yuan, Negrete, Marcos, Chen, Tianyi, Safi, Alexias, Aljamal, Abed Alhalim, Song, Lingyun, Crawford, Gregory E., Ding, Shengli, Hsu, David S., Shen, Xiling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2019
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099686/
https://www.ncbi.nlm.nih.gov/pubmed/33997167
http://dx.doi.org/10.1016/j.gendis.2019.10.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099686/
https://www.ncbi.nlm.nih.gov/pubmed/33997167
http://dx.doi.org/10.1016/j.gendis.2019.10.012

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