Randomized, phase 1/2, double-blind pioglitazone repositioning trial combined with antifungals for the treatment of cryptococcal meningitis – PIO study

BACKGROUND: Cryptococcosis affects more than 220,000 patients/year, with high mortality even when the standard treatment [amphotericin B (AMB), 5-flucytosin (5-FC) and fluconazole] is used. AMB presents high toxicity and 5-FC is not currently available in Brazil. In a pre-clinical study, pioglitazon...

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Detalles Bibliográficos
Autores principales: Gouveia-Eufrasio, Ludmila, Ribeiro, Noelly Queiroz, Santos, Julliana Ribeiro Alves, da Costa, Marliete Carvalho, Emídio, Elúzia Castro Peres, de Freitas, Gustavo José Cota, do Carmo, Paulo Henrique Fonseca, Miranda, Bárbara Alves, de Oliveira, João Carlos Maia Dornelas, da Silva, Lívia Mara Vitorino, Teixeira Leocádio, Victor Augusto, Randi Magalhães, Vanessa Caroline, Penido, Indiara, Pereira, Leonardo Soares, Rabelo, Lívia Frota, de Almeida Faria, Flávio Augusto, Teixeira Dutra, Maria Rita, Aspahan, Maíra, de Paula, Ludmila, da Silva, Dirce Inês, Tavares Melo, Márcia Gregory, de Andrade Zambelli, Virginia Antunes, Gomes Faraco, André Augusto, da Costa César, Isabela, Alves, Glauciene Prado, da Cunha Melo, Lívia Fulgêncio, de Aguiar Peres, Nalu Teixeira, Santos, Daniel Assis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099743/
https://www.ncbi.nlm.nih.gov/pubmed/33997457
http://dx.doi.org/10.1016/j.conctc.2021.100745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099743/
https://www.ncbi.nlm.nih.gov/pubmed/33997457
http://dx.doi.org/10.1016/j.conctc.2021.100745

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