SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site

SWI/SNF (BAF) chromatin remodelling complexes are key regulators of gene expression programs, and attractive drug targets for cancer therapies. Here we show that the N-terminus of the BAF155/SMARCC1 subunit contains a putative DNA-binding MarR-like domain, a chromodomain and a BRCT domain that are i...

Descripción completa

Detalles Bibliográficos
Autores principales: Allen, Mark D., Freund, Stefan M. V., Bycroft, Mark, Zinzalla, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099880/
https://www.ncbi.nlm.nih.gov/pubmed/33953332
http://dx.doi.org/10.1038/s42003-021-02050-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099880/
https://www.ncbi.nlm.nih.gov/pubmed/33953332
http://dx.doi.org/10.1038/s42003-021-02050-z

Ejemplares similares