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Highly chemoselective synthesis of hindered amides via cobalt-catalyzed intermolecular oxidative hydroamidation
α-Tertiary amides are of great importance for medicinal chemistry. However, they are often challenging to access through conventional methods due to reactivity and chemoselectivity issues. Here, we report a single-step approach towards such amides via cobalt-catalyzed intermolecular oxidative hydroa...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100129/ https://www.ncbi.nlm.nih.gov/pubmed/33953181 http://dx.doi.org/10.1038/s41467-021-22373-z |