Structures of flavivirus RNA promoters suggest two binding modes with NS5 polymerase

Flaviviruses use a ~70 nucleotide stem-loop structure called stem-loop A (SLA) at the 5′ end of the RNA genome as a promoter for RNA synthesis. Flaviviral polymerase NS5 specifically recognizes SLA to initiate RNA synthesis and methylate the 5′ guanosine cap. We report the crystal structures of deng...

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Detalles Bibliográficos
Autores principales: Lee, Eunhye, Bujalowski, Paul J., Teramoto, Tadahisa, Gottipati, Keerthi, Scott, Seth D., Padmanabhan, Radhakrishnan, Choi, Kyung H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100141/
https://www.ncbi.nlm.nih.gov/pubmed/33953197
http://dx.doi.org/10.1038/s41467-021-22846-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100141/
https://www.ncbi.nlm.nih.gov/pubmed/33953197
http://dx.doi.org/10.1038/s41467-021-22846-1

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