Adenosine-related small molecules show utility of recall antigen assay to screen compounds for off-target effects on memory T cells

Extracellular adenosine suppresses T cell immunity in the tumor microenvironment and in vitro treatment of memory T cells with adenosine can suppress antigen-mediated memory T cell expansion. We describe utilizing the recall antigen assay platform to screen small molecule drug off-target effects on...

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Detalles Bibliográficos
Autores principales: Kleiman, Eden, Sierra, Gloria, Mao, Binchen, Magcase, Dennie, George, Marybeth V., Daftarian, Pirouz M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100288/
https://www.ncbi.nlm.nih.gov/pubmed/33953256
http://dx.doi.org/10.1038/s41598-021-88965-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100288/
https://www.ncbi.nlm.nih.gov/pubmed/33953256
http://dx.doi.org/10.1038/s41598-021-88965-3

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