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Adenosine-related small molecules show utility of recall antigen assay to screen compounds for off-target effects on memory T cells
Extracellular adenosine suppresses T cell immunity in the tumor microenvironment and in vitro treatment of memory T cells with adenosine can suppress antigen-mediated memory T cell expansion. We describe utilizing the recall antigen assay platform to screen small molecule drug off-target effects on...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100288/ https://www.ncbi.nlm.nih.gov/pubmed/33953256 http://dx.doi.org/10.1038/s41598-021-88965-3 |