Perillaldehyde Inhibition of cGAS Reduces dsDNA-Induced Interferon Response

Cyclic GMP-AMP synthase (cGAS), serving as a primary sensor of intracellular DNA, is essential to initiate anti-microbial innate immunity. Inappropriate activation of cGAS by self-DNA promotes severe autoinflammatory diseases such as Aicardi–Goutières syndrome (AGS); thus, inhibition of cGAS may pro...

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Detalles Bibliográficos
Autores principales: Chu, Lei, Li, Chenhui, Li, Yongxing, Yu, Qiuya, Yu, Huansha, Li, Chunhui, Meng, Wei, Zhu, Juanjuan, Wang, Quanyi, Wang, Chen, Cui, Shufang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100446/
https://www.ncbi.nlm.nih.gov/pubmed/33968056
http://dx.doi.org/10.3389/fimmu.2021.655637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100446/
https://www.ncbi.nlm.nih.gov/pubmed/33968056
http://dx.doi.org/10.3389/fimmu.2021.655637

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