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Perillaldehyde Inhibition of cGAS Reduces dsDNA-Induced Interferon Response
Cyclic GMP-AMP synthase (cGAS), serving as a primary sensor of intracellular DNA, is essential to initiate anti-microbial innate immunity. Inappropriate activation of cGAS by self-DNA promotes severe autoinflammatory diseases such as Aicardi–Goutières syndrome (AGS); thus, inhibition of cGAS may pro...
Autores principales: | Chu, Lei, Li, Chenhui, Li, Yongxing, Yu, Qiuya, Yu, Huansha, Li, Chunhui, Meng, Wei, Zhu, Juanjuan, Wang, Quanyi, Wang, Chen, Cui, Shufang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100446/ https://www.ncbi.nlm.nih.gov/pubmed/33968056 http://dx.doi.org/10.3389/fimmu.2021.655637 |
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