Advances and Insights of APC-Asef Inhibitors for Metastatic Colorectal Cancer Therapy

In Colorectal cancer (CRC), adenomatous polyposis coli (APC) directly interacts with the Rho guanine nucleotide exchange factor 4 (Asef) and releases its GEF activity. Activated Asef promotes the aberrant migration and invasion of CRC cell through a CDC42-mediated pathway. Knockdown of either APC or...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Xiuyan, Zhong, Jie, Zhang, Qiufen, Feng, Li, Zheng, Zhen, Zhang, Jian, Lu, Shaoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100458/
https://www.ncbi.nlm.nih.gov/pubmed/33968990
http://dx.doi.org/10.3389/fmolb.2021.662579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100458/
https://www.ncbi.nlm.nih.gov/pubmed/33968990
http://dx.doi.org/10.3389/fmolb.2021.662579

Ejemplares similares