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Advances and Insights of APC-Asef Inhibitors for Metastatic Colorectal Cancer Therapy

In Colorectal cancer (CRC), adenomatous polyposis coli (APC) directly interacts with the Rho guanine nucleotide exchange factor 4 (Asef) and releases its GEF activity. Activated Asef promotes the aberrant migration and invasion of CRC cell through a CDC42-mediated pathway. Knockdown of either APC or...

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Detalles Bibliográficos
Autores principales:	Yang, Xiuyan, Zhong, Jie, Zhang, Qiufen, Feng, Li, Zheng, Zhen, Zhang, Jian, Lu, Shaoyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100458/ https://www.ncbi.nlm.nih.gov/pubmed/33968990 http://dx.doi.org/10.3389/fmolb.2021.662579

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