MD Simulations on a Well-Built Docking Model Reveal Fine Mechanical Stability and Force-Dependent Dissociation of Mac-1/GPIbα Complex

Interaction of leukocyte integrin macrophage-1 antigen (Mac-1) to platelet glycoprotein Ibα (GPIbα) is critical for platelet–leukocyte crosstalk in hemostasis and inflammatory responses to vessel injuries under hemodynamic environments. The mechano-regulation and its molecular basis for binding of M...

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Detalles Bibliográficos
Autores principales: Jiang, Xiaoyan, Sun, Xiaoxi, Lin, Jiangguo, Ling, Yingchen, Fang, Ying, Wu, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100526/
https://www.ncbi.nlm.nih.gov/pubmed/33968982
http://dx.doi.org/10.3389/fmolb.2021.638396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100526/
https://www.ncbi.nlm.nih.gov/pubmed/33968982
http://dx.doi.org/10.3389/fmolb.2021.638396

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