Inter-organelle interactions between the ER and mitotic spindle facilitates Zika protease cleavage of human Kinesin-5 and results in mitotic defects

Here we identify human Kinesin-5, Kif11/HsEg5, as a cellular target of Zika protease. We show that Zika NS2B-NS3 protease targets several sites within the motor domain of HsEg5 irrespective of motor binding to microtubules. The native integral ER-membrane protease triggers mitotic spindle positionin...

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Detalles Bibliográficos
Autores principales: Liu, Liqiong, Downs, Micquel, Guidry, Jesse, Wojcik, Edward J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100630/
https://www.ncbi.nlm.nih.gov/pubmed/33997675
http://dx.doi.org/10.1016/j.isci.2021.102385

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100630/
https://www.ncbi.nlm.nih.gov/pubmed/33997675
http://dx.doi.org/10.1016/j.isci.2021.102385

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