Transport of Drugs and Endogenous Compounds Mediated by Human OCT1: Studies in Single- and Double-Transfected Cell Models

Organic Cation Transporter 1 (OCT1, gene symbol: SLC22A1) is predominately expressed in human liver, localized in the basolateral membrane of hepatocytes and facilitates the uptake of endogenous compounds (e.g. serotonin, acetylcholine, thiamine), and widely prescribed drugs (e.g. metformin, fenoter...

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Detalles Bibliográficos
Autores principales: Haberkorn, Bastian, Fromm, Martin F., König, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100673/
https://www.ncbi.nlm.nih.gov/pubmed/33967805
http://dx.doi.org/10.3389/fphar.2021.662535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100673/
https://www.ncbi.nlm.nih.gov/pubmed/33967805
http://dx.doi.org/10.3389/fphar.2021.662535

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