Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma

Phosphatidylserine (PS) is exposed on the surface of apoptotic cells and is known to promote immunosuppressive signals in the tumor microenvironment (TME). Antibodies that block PS interaction with its receptors have been shown to repolarize the TME into a proinflammatory state. Radiation therapy (R...

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Detalles Bibliográficos
Autores principales: Budhu, Sadna, Giese, Rachel, Gupta, Aditi, Fitzgerald, Kelly, Zappasodi, Roberta, Schad, Sara, Hirschhorn, Daniel, Campesato, Luis Felipe, De Henau, Olivier, Gigoux, Mathieu, Liu, Cailian, Mazo, Gregory, Deng, Liang, Barker, Christopher A., Wolchok, Jedd D., Merghoub, Taha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100747/
https://www.ncbi.nlm.nih.gov/pubmed/33440157
http://dx.doi.org/10.1016/j.celrep.2020.108620

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100747/
https://www.ncbi.nlm.nih.gov/pubmed/33440157
http://dx.doi.org/10.1016/j.celrep.2020.108620

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