Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry

Liquid-assisted mechanochemistry as a versatile approach for the coupling of a nucleoside phosphoramidite with a 5′-OH partially protected nucleoside has been investigated. Noted advantages over reported methods were a simplified reaction protocol, a drastic reduction in the use of toxic solvents, t...

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Detalles Bibliográficos
Autores principales: Johnston, C., Hardacre, C., Migaud, M. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101013/
https://www.ncbi.nlm.nih.gov/pubmed/34035937
http://dx.doi.org/10.1098/rsos.201703
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author Johnston, C.
Hardacre, C.
Migaud, M. E.
author_facet Johnston, C.
Hardacre, C.
Migaud, M. E.
author_sort Johnston, C.
collection PubMed
description Liquid-assisted mechanochemistry as a versatile approach for the coupling of a nucleoside phosphoramidite with a 5′-OH partially protected nucleoside has been investigated. Noted advantages over reported methods were a simplified reaction protocol, a drastic reduction in the use of toxic solvents, the facilitation of mechanochemical reactions through the improved mixing of solid reagents, and low hydrolytic product formation.
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spelling pubmed-81010132021-05-24 Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry Johnston, C. Hardacre, C. Migaud, M. E. R Soc Open Sci Chemistry Liquid-assisted mechanochemistry as a versatile approach for the coupling of a nucleoside phosphoramidite with a 5′-OH partially protected nucleoside has been investigated. Noted advantages over reported methods were a simplified reaction protocol, a drastic reduction in the use of toxic solvents, the facilitation of mechanochemical reactions through the improved mixing of solid reagents, and low hydrolytic product formation. The Royal Society 2021-03-31 /pmc/articles/PMC8101013/ /pubmed/34035937 http://dx.doi.org/10.1098/rsos.201703 Text en © 2021 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Chemistry
Johnston, C.
Hardacre, C.
Migaud, M. E.
Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry
title Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry
title_full Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry
title_fullStr Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry
title_full_unstemmed Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry
title_short Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry
title_sort investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101013/
https://www.ncbi.nlm.nih.gov/pubmed/34035937
http://dx.doi.org/10.1098/rsos.201703
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