Cargando…

Reduction in pericyte coverage leads to blood–brain barrier dysfunction via endothelial transcytosis following chronic cerebral hypoperfusion

BACKGROUND: Chronic cerebral hypoperfusion (CCH) is the leading cause of cerebral small vessel disease (CSVD). CCH is strongly associated with blood–brain barrier (BBB) dysfunction and white matter lesions (WMLs) in CSVD. However, the effects of CCH on BBB integrity and components and the cellular a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Zhengyu, Gao, Chenhao, Gao, Dandan, Sun, Ruihua, Li, Wei, Wang, Fengyu, Wang, Yanliang, Cao, Huixia, Zhou, Guoyu, Zhang, Jiewen, Shang, Junkui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101037/ https://www.ncbi.nlm.nih.gov/pubmed/33952281 http://dx.doi.org/10.1186/s12987-021-00255-2

Ejemplares similares

Both the Complexity of Tight Junctions and Endothelial Transcytosis Are Increased During BBB Postnatal Development in Rats
por: Li, Wei, et al.
Publicado: (2022)

Mechanisms regulating cerebral hypoperfusion in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
por: Yan, Xi, et al.
Publicado: (2022)

A Chinese SCA36 pedigree analysis of NOP56 expansion region based on long-read sequencing
por: Zou, Jinlong, et al.
Publicado: (2023)

Decreased mitochondrial D-loop region methylation mediates an increase in mitochondrial DNA copy number in CADASIL
por: Zhang, Jiewen, et al.
Publicado: (2022)

Brain pericytes increase the lipopolysaccharide-enhanced transcytosis of HIV-1 free virus across the in vitro blood–brain barrier: evidence for cytokine-mediated pericyte-endothelial cell crosstalk
por: Dohgu, Shinya, et al.
Publicado: (2013)

Effects of different regional cerebral blood flow on white matter hyperintensity in CADASIL patients
por: Wang, Runrun, et al.
Publicado: (2022)

Novel PSEN1 (P284S) Mutation Causes Alzheimer's Disease with Cerebellar Amyloid β-Protein Deposition
por: Xia, Mingrong, et al.
Publicado: (2022)

Overview of Crosstalk Between Multiple Factor of Transcytosis in Blood Brain Barrier
por: Tjakra, Marco, et al.
Publicado: (2020)

Endothelial Transcytosis of Lipoproteins in Atherosclerosis
por: Zhang, Xinbo, et al.
Publicado: (2018)

Pathogenic bacteria exploit transferrin receptor transcytosis to penetrate the blood–brain barrier
por: Cheng, Zhihui, et al.
Publicado: (2023)

Caveolae-Mediated Endothelial Transcytosis across the Blood-Brain Barrier in Acute Ischemic Stroke
por: Zhou, Min, et al.
Publicado: (2021)

Pericyte‐derived bone morphogenetic protein 4 underlies white matter damage after chronic hypoperfusion
por: Uemura, Maiko T., et al.
Publicado: (2017)

A Human Blood-Brain Barrier Transcytosis Assay Reveals Antibody Transcytosis Influenced by pH-Dependent Receptor Binding
por: Sade, Hadassah, et al.
Publicado: (2014)

Transcytosis to Cross the Blood Brain Barrier, New Advancements and Challenges
por: Pulgar, Victor M.
Publicado: (2019)

Intracellular transport and regulation of transcytosis across the blood–brain barrier
por: Villaseñor, Roberto, et al.
Publicado: (2018)

Suppression of transcytosis regulates zebrafish blood-brain barrier function
por: O'Brown, Natasha M, et al.
Publicado: (2019)

Chemical biology tools for probing transcytosis at the blood–brain barrier
por: Beard, Rhiannon, et al.
Publicado: (2019)

Wnt signaling activates MFSD2A to suppress vascular endothelial transcytosis and maintain blood-retinal barrier
por: Wang, Zhongxiao, et al.
Publicado: (2020)

Storax Inhibits Caveolae-Mediated Transcytosis at Blood-Brain Barrier After Ischemic Stroke in Rats
por: Zhou, Min, et al.
Publicado: (2022)

Differing associations between Aβ accumulation, hypoperfusion, blood–brain barrier dysfunction and loss of PDGFRB pericyte marker in the precuneus and parietal white matter in Alzheimer's disease
por: Miners, J Scott, et al.
Publicado: (2017)

Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier
por: Ayloo, Swathi, et al.
Publicado: (2022)

Central role for PICALM in amyloid–β blood–brain barrier transcytosis and clearance
por: Zhao, Zhen, et al.
Publicado: (2015)

Syndapin-2 mediated transcytosis of amyloid-β across the blood–brain barrier
por: M. Leite, Diana, et al.
Publicado: (2022)

Glycocalyx is critical for blood‐brain barrier integrity by suppressing caveolin1‐dependent endothelial transcytosis following ischemic stroke
por: Zhu, Juan, et al.
Publicado: (2021)

Biology and function of pericytes in the vascular microcirculation
por: Wu, Yue, et al.
Publicado: (2023)

Encephalitic Alphaviruses Exploit Caveola-Mediated Transcytosis at the Blood-Brain Barrier for Central Nervous System Entry
por: Salimi, Hamid, et al.
Publicado: (2020)

Transcytosis in thyroid follicle cells
Publicado: (1983)

Transcytosis of albumin in capillary endothelium
Publicado: (1987)

Transcytosis of Staphylococcal Superantigen Toxins
por: Hamad, Abdel Rahim A., et al.
Publicado: (1997)

Endocytosis and transcytosis of gliadin peptides
por: Barone, M. Vittoria, et al.
Publicado: (2016)

Plastic roles of pericytes in the blood–retinal barrier
por: Park, Do Young, et al.
Publicado: (2017)

Ebola virus disrupts the inner blood-retinal barrier by induction of vascular endothelial growth factor in pericytes
por: Gao, Jiawang, et al.
Publicado: (2023)

A New Function for the LDL Receptor: Transcytosis of LDL across the Blood–Brain Barrier
por: Dehouck, Bénédicte, et al.
Publicado: (1997)

Transcytosis in the blood–cerebrospinal fluid barrier of the mouse brain with an engineered receptor/ligand system
por: Méndez-Gómez, Héctor R, et al.
Publicado: (2015)

Investigating receptor-mediated antibody transcytosis using blood–brain barrier organoid arrays
por: Simonneau, Claire, et al.
Publicado: (2021)

Physical exercise promotes astrocyte coverage of microvessels in a model of chronic cerebral hypoperfusion
por: Leardini-Tristão, Marina, et al.
Publicado: (2020)

CRP-Induced NLRP3 Inflammasome Activation Increases LDL Transcytosis Across Endothelial Cells
por: Bian, Fang, et al.
Publicado: (2019)

Pericyte derived chemokines amplify neutrophil recruitment across the cerebrovascular endothelial barrier
por: Gil, Eliza, et al.
Publicado: (2022)

Quantitative assessment of angiogenesis and pericyte coverage in human cell-derived vascular sprouts
por: Eglinger, Jan, et al.
Publicado: (2017)

LDL-Cholesterol Increases the Transcytosis of Molecules through Endothelial Monolayers
por: Magalhaes, Ana, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_6p4nv6tbng7ai84begdrk7g2ed