Determination of complete chromosomal haplotypes by bulk DNA sequencing

Haplotype phase represents the collective genetic variation between homologous chromosomes and is an essential feature of non-haploid genomes. Here we describe a computational strategy to reliably determine complete whole-chromosome haplotypes using a combination of bulk long-range sequencing and Hi...

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Detalles Bibliográficos
Autores principales: Tourdot, Richard W., Brunette, Gregory J., Pinto, Ricardo A., Zhang, Cheng-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101039/
https://www.ncbi.nlm.nih.gov/pubmed/33957932
http://dx.doi.org/10.1186/s13059-021-02330-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101039/
https://www.ncbi.nlm.nih.gov/pubmed/33957932
http://dx.doi.org/10.1186/s13059-021-02330-1

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