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Overexpression of TNFα induces senescence, autophagy and mitochondrial dysfunctions in melanoma cells

BACKGROUND: Tumor necrosis factor alpha (TNFα) is a pleiotropic cytokine with both anti-tumorigenic and pro-tumorigenic activity, affecting tumor cell biology, the balance between cell survival and death. The final effect of TNFα is dependent on the type of malignant cells, with the potential to arr...

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Detalles Bibliográficos
Autores principales: Tyciakova, Silvia, Valova, Valeria, Svitkova, Barbora, Matuskova, Miroslava
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101174/
https://www.ncbi.nlm.nih.gov/pubmed/33957885
http://dx.doi.org/10.1186/s12885-021-08237-1