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Identification of neutrophil β2-integrin LFA-1 as a potential mechanistic biomarker in ANCA-associated vasculitis via microarray and validation analyses

BACKGROUND: Leukocyte activation by anti-neutrophil cytoplasmic antibody (ANCA) and the subsequent leukocyte–endothelium interaction play a key role in the development of endothelial damage in ANCA-associated vasculitis (AAV). In contrast to that of leukocyte activation, the exact role of the leukoc...

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Detalles Bibliográficos
Autores principales: Matsumoto, Kotaro, Kurasawa, Takahiko, Yoshimoto, Keiko, Suzuki, Katsuya, Takeuchi, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101175/
https://www.ncbi.nlm.nih.gov/pubmed/33957974
http://dx.doi.org/10.1186/s13075-021-02510-1