Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8(+) T cells

The molecular properties of CD8(+) T cells that respond to SARS-CoV-2 infection are not fully known. Here, we report on the single-cell transcriptomes of >80,000 virus-reactive CD8(+) T cells, obtained using a modified Antigen-Reactive T cell Enrichment (ARTE) assay, from 39 COVID-19 patients and...

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Detalles Bibliográficos
Autores principales: Kusnadi, Anthony, Ramírez-Suástegui, Ciro, Fajardo, Vicente, Chee, Serena J, Meckiff, Benjamin J, Simon, Hayley, Pelosi, Emanuela, Seumois, Grégory, Ay, Ferhat, Vijayanand, Pandurangan, Ottensmeier, Christian H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101257/
https://www.ncbi.nlm.nih.gov/pubmed/33478949
http://dx.doi.org/10.1126/sciimmunol.abe4782

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101257/
https://www.ncbi.nlm.nih.gov/pubmed/33478949
http://dx.doi.org/10.1126/sciimmunol.abe4782

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