Cargando…

Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8(+) T cells

The molecular properties of CD8(+) T cells that respond to SARS-CoV-2 infection are not fully known. Here, we report on the single-cell transcriptomes of >80,000 virus-reactive CD8(+) T cells, obtained using a modified Antigen-Reactive T cell Enrichment (ARTE) assay, from 39 COVID-19 patients and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kusnadi, Anthony, Ramírez-Suástegui, Ciro, Fajardo, Vicente, Chee, Serena J, Meckiff, Benjamin J, Simon, Hayley, Pelosi, Emanuela, Seumois, Grégory, Ay, Ferhat, Vijayanand, Pandurangan, Ottensmeier, Christian H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101257/ https://www.ncbi.nlm.nih.gov/pubmed/33478949 http://dx.doi.org/10.1126/sciimmunol.abe4782

Ejemplares similares

Severely ill COVID-19 patients display augmented functional properties in SARS-CoV-2-reactive CD8(+) T cells
por: Kusnadi, Anthony, et al.
Publicado: (2020)

Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4(+) T Cells in COVID-19
por: Meckiff, Benjamin J., et al.
Publicado: (2020)

Identification of significant chromatin contacts from HiChIP data by FitHiChIP
por: Bhattacharyya, Sourya, et al.
Publicado: (2019)

17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells
por: Schmiedel, Benjamin Joachim, et al.
Publicado: (2016)

COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types.
por: Schmiedel, Benjamin J., et al.
Publicado: (2020)

COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types
por: Schmiedel, Benjamin J., et al.
Publicado: (2021)

Multi–cell type gene coexpression network analysis reveals coordinated interferon response and cross–cell type correlations in systemic lupus erythematosus
por: Panwar, Bharat, et al.
Publicado: (2021)

Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer
por: Clarke, James, et al.
Publicado: (2019)

Evaluating the effect of immune cells on the outcome of patients with mesothelioma
por: Chee, Serena J, et al.
Publicado: (2017)

Predicting Cell Types and Genetic Variations Contributing to Disease by Combining GWAS and Epigenetic Data
por: Gerasimova, Anna, et al.
Publicado: (2013)

The Challenge of Distinguishing Cell–Cell Complexes from Singlet Cells in Non‐Imaging Flow Cytometry and Single‐Cell Sorting
por: Burel, Julie G., et al.
Publicado: (2020)

M1(hot) tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer
por: Garrido-Martin, Eva M, et al.
Publicado: (2020)

CyTOF mass cytometry reveals phenotypically distinct human blood neutrophil populations differentially correlated with melanoma stage
por: Zhu, Yanfang Peipei, et al.
Publicado: (2020)

Identification of a novel cis-regulatory element essential for immune tolerance
por: LaFlam, Taylor N., et al.
Publicado: (2015)

Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs
por: Eschweiler, Simon, et al.
Publicado: (2022)

EGF-Induced Bronchial Epithelial Cells Drive Neutrophil Chemotactic and Anti-Apoptotic Activity in Asthma
por: Uddin, Mohib, et al.
Publicado: (2013)

Constitutive Activation of Natural Killer Cells in Primary Biliary Cholangitis
por: Hydes, Theresa J., et al.
Publicado: (2019)

Gene expression analysis of TIL rich HPV-driven head and neck tumors reveals a distinct B-cell signature when compared to HPV independent tumors
por: Wood, Oliver, et al.
Publicado: (2016)

Human CD79b(+) neutrophils in the blood are associated with early-stage melanoma
por: Meyer, Melissa A., et al.
Publicado: (2023)

Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers
por: Lee, Jeong Hyun, et al.
Publicado: (2020)

T cells in multiple myeloma display features of exhaustion and senescence at the tumor site
por: Zelle-Rieser, Claudia, et al.
Publicado: (2016)

Quantitative and Qualitative Perturbations of CD8(+) MAITs in Healthy Mycobacterium tuberculosis–Infected Individuals
por: Pomaznoy, Mikhail, et al.
Publicado: (2020)

CD4+CCR6+ T cells dominate the BCG-induced transcriptional signature
por: Singhania, Akul, et al.
Publicado: (2021)

Male Mutation Bias Is the Main Force Shaping Chromosomal Substitution Rates in Monotreme Mammals
por: Link, Vivian, et al.
Publicado: (2017)

Transcriptome and chromatin landscape of iNKT cells are shaped by subset differentiation and antigen exposure
por: Murray, Mallory Paynich, et al.
Publicado: (2021)

A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies
por: Cayford, Justin, et al.
Publicado: (2020)

The relationships between teachers’ emotional labor and display rules, trait emotions, exhaustion, and classroom emotional climate
por: Ma, Pei, et al.
Publicado: (2023)

Emotional exhaustion among healthcare professionals: the effects of role ambiguity, work engagement and professional commitment
por: Chiara, Panari, et al.
Publicado: (2019)

Peripheral natural killer cells in chronic hepatitis B patients display multiple molecular features of T cell exhaustion
por: Marotel, Marie, et al.
Publicado: (2021)

Chronic myeloid leukaemia patients at diagnosis and resistant to tyrosine kinase inhibitor therapy display exhausted T‐cell phenotype
por: Harrington, Patrick, et al.
Publicado: (2022)

Vancomycin-Induced Maturation Arrest with Reactive Promyelocyte Proliferation: A Diagnostic and Therapeutic Challenge
por: Jamal, Iffat, et al.
Publicado: (2022)

Divergent metabolic programmes control two populations of MAIT cells that protect the lung
por: Riffelmacher, Thomas, et al.
Publicado: (2023)

Reactive astrocytes in ALS display diminished intron retention
por: Ziff, Oliver J, et al.
Publicado: (2021)

The T-cell Response to Epstein-Barr Virus–New Tricks From an Old Dog
por: Long, Heather M., et al.
Publicado: (2019)

ThymicPeptides Reverse Immune Exhaustion in Patients with Reactivated Human Alphaherpesvirus1 Infections
por: Hymos, Anna, et al.
Publicado: (2020)

Eco-friendly salt/alkali-free exhaustion dyeing of cotton fabric with reactive dyes
por: Aysha, Tarek S., et al.
Publicado: (2022)

Double Positive CD4(+)CD8(+) (DP) T-Cells Display Distinct Exhaustion Phenotype in Chronic Hepatitis C
por: Kochanowicz, Anna Maria, et al.
Publicado: (2023)

Transcriptomics of Acute DENV-Specific CD8+ T Cells Does Not Support Qualitative Differences as Drivers of Disease Severity
por: Grifoni, Alba, et al.
Publicado: (2022)

Single-cell profiling reveals distinct subsets of CD14+ monocytes drive blood immune signatures of active tuberculosis
por: Hillman, Hannah, et al.
Publicado: (2023)

Exhaust the exhausters: Targeting regulatory T cells in the tumor microenvironment
por: McRitchie, Bayley R., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_iac584bqmp2olvv1fs28u74t1k