Inner-nuclear-membrane–associated degradation employs Dfm1-independent retrotranslocation and alleviates misfolded transmembrane-protein toxicity

Before their delivery to and degradation by the 26S proteasome, misfolded transmembrane proteins of the endoplasmic reticulum (ER) and inner–nuclear membrane (INM) must be extracted from lipid bilayers. This extraction process, known as retrotranslocation, requires both quality-control E3 ubiquitin...

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Detalles Bibliográficos
Autores principales: Flagg, Matthew P., Wangeline, Margaret A., Holland, Sarah R., Duttke, Sascha H., Benner, Christopher, Neal, Sonya, Hampton, Randolph Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101470/
https://www.ncbi.nlm.nih.gov/pubmed/33566711
http://dx.doi.org/10.1091/mbc.E20-11-0720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101470/
https://www.ncbi.nlm.nih.gov/pubmed/33566711
http://dx.doi.org/10.1091/mbc.E20-11-0720

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