PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype

Programmed cell death protein 1 (PD-1) is expressed on T cells upon T cell receptor (TCR) stimulation. PD-1 ligand 1 (PD-L1) is expressed in most tumor environments, and its binding to PD-1 on T cells drives them to apoptosis or into a regulatory phenotype. The fact that PD-L1 itself is also express...

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Detalles Bibliográficos
Autores principales: Fanelli, Giorgia, Romano, Marco, Nova-Lamperti, Estefania, Werner Sunderland, Mariana, Nerviani, Alessandra, Scottà, Cristiano, Bombardieri, Michele, Quezada, Sergio A., Sacks, Steven H., Noelle, Randolph J., Pitzalis, Costantino, Lechler, Robert I., Lombardi, Giovanna, Becker, Pablo D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101994/
https://www.ncbi.nlm.nih.gov/pubmed/33901179
http://dx.doi.org/10.1371/journal.pbio.3001199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101994/
https://www.ncbi.nlm.nih.gov/pubmed/33901179
http://dx.doi.org/10.1371/journal.pbio.3001199

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