Origin and evolution of the zinc finger antiviral protein

The human zinc finger antiviral protein (ZAP) recognizes RNA by binding to CpG dinucleotides. Mammalian transcriptomes are CpG-poor, and ZAP may have evolved to exploit this feature to specifically target non-self viral RNA. Phylogenetic analyses reveal that ZAP and its paralogue PARP12 share an anc...

Descripción completa

Detalles Bibliográficos
Autores principales: Gonçalves-Carneiro, Daniel, Takata, Matthew A., Ong, Heley, Shilton, Amanda, Bieniasz, Paul D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102003/
https://www.ncbi.nlm.nih.gov/pubmed/33901262
http://dx.doi.org/10.1371/journal.ppat.1009545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102003/
https://www.ncbi.nlm.nih.gov/pubmed/33901262
http://dx.doi.org/10.1371/journal.ppat.1009545

Ejemplares similares