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Origin and evolution of the zinc finger antiviral protein
The human zinc finger antiviral protein (ZAP) recognizes RNA by binding to CpG dinucleotides. Mammalian transcriptomes are CpG-poor, and ZAP may have evolved to exploit this feature to specifically target non-self viral RNA. Phylogenetic analyses reveal that ZAP and its paralogue PARP12 share an anc...
Autores principales: | Gonçalves-Carneiro, Daniel, Takata, Matthew A., Ong, Heley, Shilton, Amanda, Bieniasz, Paul D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102003/ https://www.ncbi.nlm.nih.gov/pubmed/33901262 http://dx.doi.org/10.1371/journal.ppat.1009545 |
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