Cargando…

Post-transcriptional repression of circadian component CLOCK regulates cancer-stemness in murine breast cancer cells

Disruption of the circadian clock machinery in cancer cells is implicated in tumor malignancy. Studies on cancer therapy reveal the presence of heterogeneous cells, including breast cancer stem-like cells (BCSCs), in breast tumors. BCSCs are often characterized by high aldehyde dehydrogenase (ALDH)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ogino, Takashi, Matsunaga, Naoya, Tanaka, Takahiro, Tanihara, Tomohito, Terajima, Hideki, Yoshitane, Hikari, Fukada, Yoshitaka, Tsuruta, Akito, Koyanagi, Satoru, Ohdo, Shigehiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102063/ https://www.ncbi.nlm.nih.gov/pubmed/33890571 http://dx.doi.org/10.7554/eLife.66155

Ejemplares similares

RNA editing enzyme ADAR1 governs the circadian expression of P-glycoprotein in human renal cells by regulating alternative splicing of the ABCB1 gene
por: Omata, Yuji, et al.
Publicado: (2021)

Dysfunction of the circadian transcriptional factor CLOCK in mice resists chemical carcinogen-induced tumorigenesis
por: Hashikawa, Ken-ichi, et al.
Publicado: (2017)

A-to-I RNA editing enzyme ADAR2 regulates light-induced circadian phase-shift
por: Terajima, Hideki, et al.
Publicado: (2018)

RNA editing enzyme ADAR1 controls miR-381-3p-mediated expression of multidrug resistance protein MRP4 via regulation of circRNA in human renal cells
por: Omata, Yuji, et al.
Publicado: (2022)

Diurnal Expression of PD-1 on Tumor-Associated Macrophages Underlies the Dosing Time-Dependent Antitumor Effects of the PD-1/PD-L1 Inhibitor BMS-1 in B16/BL6 Melanoma-Bearing Mice
por: Tsuruta, Akito, et al.
Publicado: (2022)

Cell-based inhibitor screening identifies multiple protein kinases important for circadian clock oscillations
por: Kon, Naohiro, et al.
Publicado: (2015)

Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis
por: Yoshida, Yuya, et al.
Publicado: (2021)

Salt-inducible kinase 3 regulates the mammalian circadian clock by destabilizing PER2 protein
por: Hayasaka, Naoto, et al.
Publicado: (2017)

Correction: Salt-inducible kinase 3 regulates the mammalian circadian clock by destabilizing PER2 protein
por: Hayasaka, Naoto, et al.
Publicado: (2021)

ASK family kinases mediate cellular stress and redox signaling to circadian clock
por: Imamura, Kiyomichi, et al.
Publicado: (2018)

Circadian clock component PERIOD2 regulates diurnal expression of Na(+)/H(+) exchanger regulatory factor-1 and its scaffolding function
por: Tsurudome, Yuya, et al.
Publicado: (2018)

USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock
por: Hirano, Arisa, et al.
Publicado: (2016)

Functional D-box sequences reset the circadian clock and drive mRNA rhythms
por: Yoshitane, Hikari, et al.
Publicado: (2019)

The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S
por: Hayashi, Yoshinori, et al.
Publicado: (2013)

Diurnal expression of MRP4 in bone marrow cells underlies the dosing-time dependent changes in the oxaliplatin-induced myelotoxicity
por: Kato, Mizuki, et al.
Publicado: (2020)

Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch
por: Masuda, Shusaku, et al.
Publicado: (2020)

The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor
por: Gossan, Nicole C., et al.
Publicado: (2014)

Kinase signaling in distinct neuronal populations in the mouse brain controls sleep homeostasis and the circadian clock
por: Fukada, Yoshitaka
Publicado: (2023)

Evolution of the repression mechanisms in circadian clocks
por: Tyler, Jonathan, et al.
Publicado: (2022)

The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis
por: Pekovic-Vaughan, Vanja, et al.
Publicado: (2014)

Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain
por: Kusunose, Naoki, et al.
Publicado: (2010)

Adiponectin regulates the circadian rhythm of glucose and lipid metabolism
por: Wada, Taira, et al.
Publicado: (2022)

Rhythmic transcription of Bmal1 stabilizes the circadian timekeeping system in mammals
por: Abe, Yasuko O., et al.
Publicado: (2022)

Singularity response reveals entrainment properties in mammalian circadian clock
por: Masuda, Kosaku, et al.
Publicado: (2023)

Attenuated SIRT1 Activity Leads to PER2 Cytoplasmic Localization and Dampens the Amplitude of Bmal1 Promoter-Driven Circadian Oscillation
por: Ashimori, Atsushige, et al.
Publicado: (2021)

CaMKII is essential for the cellular clock and coupling between morning and evening behavioral rhythms
por: Kon, Naohiro, et al.
Publicado: (2014)

The circadian clock in the piriform cortex intrinsically tunes daily changes of odor-evoked neural activity
por: Takeuchi, Shunsuke, et al.
Publicado: (2023)

Arabidopsis Circadian Clock Repress Phytochrome a Signaling
por: Liu, Yang, et al.
Publicado: (2022)

Identification of the Repressive Domain of the Negative Circadian Clock Component CHRONO
por: Yang, Yu, et al.
Publicado: (2020)

Circadian Clock, Cancer, and Chemotherapy
por: Sancar, Aziz, et al.
Publicado: (2014)

Circadian clocks and breast cancer
por: Blakeman, Victoria, et al.
Publicado: (2016)

Circadian clock and oral cancer
por: Nirvani, Minou, et al.
Publicado: (2018)

Circadian Clock and Liver Cancer
por: Crespo, María, et al.
Publicado: (2021)

Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease
por: Matsunaga, Naoya, et al.
Publicado: (2016)

Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia
por: Koyanagi, Satoru, et al.
Publicado: (2016)

Thyroid Cancer and Circadian Clock Disruption
por: Malaguarnera, Roberta, et al.
Publicado: (2020)

Major roles of the circadian clock in cancer
por: Huang, Chen, et al.
Publicado: (2023)

The circadian clock is disrupted in pancreatic cancer
por: Schwartz, Patrick B., et al.
Publicado: (2023)

Molecular encoding and synaptic decoding of context during salt chemotaxis in C. elegans
por: Hiroki, Shingo, et al.
Publicado: (2022)

The CK2 Kinase Stabilizes CLOCK and Represses Its Activity in the Drosophila Circadian Oscillator
por: Szabó, Áron, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_75s9e9unctdsi5ehsh2evf5cja