An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma

Cancer cells undergo lineage switching during natural progression and in response to therapy. NKX2-1 loss in human and murine lung adenocarcinoma leads to invasive mucinous adenocarcinoma (IMA), a lung cancer subtype that exhibits gastric differentiation and harbors a distinct spectrum of driver onc...

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Detalles Bibliográficos
Autores principales: Zewdu, Rediet, Mehrabad, Elnaz Mirzaei, Ingram, Kelley, Fang, Pengshu, Gillis, Katherine L, Camolotto, Soledad A, Orstad, Grace, Jones, Alex, Mendoza, Michelle C, Spike, Benjamin T, Snyder, Eric L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102067/
https://www.ncbi.nlm.nih.gov/pubmed/33821796
http://dx.doi.org/10.7554/eLife.66788

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102067/
https://www.ncbi.nlm.nih.gov/pubmed/33821796
http://dx.doi.org/10.7554/eLife.66788

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