Patient-Derived Mutant Forms of NFE2L2/NRF2 Drive Aggressive Murine Hepatoblastomas

BACKGROUND & AIMS: Hepatoblastoma (HB), the most common pediatric liver cancer, often bears β-catenin mutations and deregulates the Hippo tumor suppressor pathway. Murine HBs can be generated by co-expressing β-catenin mutants and the constitutively active Hippo effector YAP(S127A). Some HBs and...

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Detalles Bibliográficos
Autores principales: Wang, Huabo, Lu, Jie, Mandel, Jordan A., Zhang, Weiqi, Schwalbe, Marie, Gorka, Joanna, Liu, Ying, Marburger, Brady, Wang, Jinglin, Ranganathan, Sarangarajan, Prochownik, Edward V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102178/
https://www.ncbi.nlm.nih.gov/pubmed/33618031
http://dx.doi.org/10.1016/j.jcmgh.2021.02.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102178/
https://www.ncbi.nlm.nih.gov/pubmed/33618031
http://dx.doi.org/10.1016/j.jcmgh.2021.02.004

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