Cargando…

Menin is necessary for long term maintenance of meningioma-1 driven leukemia

Translocations of Meningioma-1 (MN1) occur in a subset of acute myeloid leukemias (AML) and result in high expression of MN1, either as a full-length protein, or as a fusion protein that includes most of the N-terminus of MN1. High levels of MN1 correlate with poor prognosis. When overexpressed in m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Libbrecht, Clara, Xie, Hongbo M., Kingsley, Molly C., Haladyna, Jessica N., Riedel, Simone S., Alikarami, Fatemeh, Lenard, Alexandra, McGeehan, Gerard M., Ernst, Patricia, Bernt, Kathrin M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102197/ https://www.ncbi.nlm.nih.gov/pubmed/33542482 http://dx.doi.org/10.1038/s41375-021-01146-z

Ejemplares similares

The MLL–Menin Interaction is a Therapeutic Vulnerability in NUP98-rearranged AML
por: Rasouli, Milad, et al.
Publicado: (2023)

The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML
por: Heikamp, Emily B., et al.
Publicado: (2022)

Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes
por: Sparbier, Christina E., et al.
Publicado: (2023)

The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia
por: Issa, Ghayas C., et al.
Publicado: (2023)

Inhibition of menin, BCL-2, and FLT3 combined with a hypomethylating agent cures NPM1/FLT3-ITD/-TKD mutant acute myeloid leukemia in a patient-derived xenograft model
por: Carter, Bing Z., et al.
Publicado: (2023)

Fyn-mediated phosphorylation of Menin disrupts telomere maintenance in stem cells
por: Paul, Souren, et al.
Publicado: (2023)

Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
por: Fiskus, Warren, et al.
Publicado: (2022)

Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1
por: Fiskus, Warren, et al.
Publicado: (2023)

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism
por: Chou, Chih-Wei, et al.
Publicado: (2020)

IKAROS and MENIN Coordinate Therapeutically Actionable Leukaemogenic Gene Expression in MLL-r Acute Myeloid Leukaemia
por: Aubrey, Brandon J., et al.
Publicado: (2022)

S125: NON-GENETIC RESISTANCE TO MENIN INHIBITION IN AML IS REVERSIBLE BY PERTURBATION OF KAT6A
por: Perner, Florian, et al.
Publicado: (2023)

The role of menin in bone pathology
por: Gorbacheva, Anna, et al.
Publicado: (2022)

FBP1 Is an Interacting Partner of Menin
por: Zaman, Shadia, et al.
Publicado: (2014)

Menin: Expanding and dichotomous roles in cancer
por: Katona, Bryson W., et al.
Publicado: (2019)

Kmt2a cooperates with menin to suppress tumorigenesis in mouse pancreatic islets
por: Lin, Wenchu, et al.
Publicado: (2016)

Endotracheal Involvement as an Unusual Extranodal Site of Recurrence from Mantle Cell Lymphoma
por: Verde, Franco, et al.
Publicado: (2015)

Investigating the novel-binding site of RPA2 on Menin and predicting the effect of point mutation of Menin through protein–protein interactions
por: Kaur, Gurjeet, et al.
Publicado: (2023)

Abstract 36: Menin Functions Critically In Mesenchymal Stem Cells And Osteoblast Progenitors To Promote Bone Development And Maintenance In Vivo
por: Abi-Rafeh, Jad, et al.
Publicado: (2020)

MON-923 MENIN Gene Mutation: Unity Amidst Diversity
por: Rais, Nadeem M, et al.
Publicado: (2020)

Multi-omics analyses of MEN1 missense mutations identify disruption of menin–MLL and menin–JunD interactions as critical requirements for molecular pathogenicity
por: Dreijerink, Koen M. A., et al.
Publicado: (2022)

Purification and characterization of recombinant human renin for X-ray crystallization studies
por: Wu, Zhongren, et al.
Publicado: (2008)

Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia
por: Danis, Etienne, et al.
Publicado: (2016)

Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target
por: Brzezinka, Krzysztof, et al.
Publicado: (2020)

Investigating the Effects of Amino Acid Variations in Human Menin
por: Biancaniello, Carmen, et al.
Publicado: (2022)

Hypothalamic Menin regulates systemic aging and cognitive decline
por: Leng, Lige, et al.
Publicado: (2023)

Development of an orally bioavailable selective inhibitor of the menin-MLL
por: Zhong, Hai-Jing, et al.
Publicado: (2022)

Dissection of the MEF2D-IRF8 transcriptional circuit dependency in acute myeloid leukemia
por: Pingul, Bianca Y., et al.
Publicado: (2022)

Structural Analysis of Mitochondrial Mutations Reveals a Role for Bigenomic Protein Interactions in Human Disease
por: Lloyd, Rhiannon E., et al.
Publicado: (2013)

Menin and p53 have non-synergistic effects on tumorigenesis in mice
por: Loffler, Kelly A, et al.
Publicado: (2012)

Menin Links the Stress Response to Genome Stability in Drosophila melanogaster
por: Papaconstantinou, Maria, et al.
Publicado: (2010)

The Menin Tumor Suppressor Protein Is Phosphorylated in Response to DNA Damage
por: Francis, Joshua, et al.
Publicado: (2011)

Consequence of Menin Deficiency in Mouse Adipocytes Derived by In Vitro Differentiation
por: Parekh, Vaishali I., et al.
Publicado: (2015)

Loss of tumor suppressor menin expression in high grade cholangiocarcinomas
por: Lairmore, Terry C., et al.
Publicado: (2023)

HGG-24. A NOVEL ONCOGENIC ROLE FOR MENIN IN GLIOMA
por: Yang, Yanhong, et al.
Publicado: (2023)

A metastable structure for the compact 30‐nm chromatin fibre
por: Wu, Chenyi, et al.
Publicado: (2016)

An Optoelectronics-Based Compressive Force Sensor with Scalable Sensitivity
por: Pennel, Zachary, et al.
Publicado: (2023)

LBODP106 Multi-omics Analyses Of MEN1 Missense Mutations Identify Disruption Of Menin-MLL And Menin-JunD Interactions As Critical Requirements For Molecular Pathogenicity
por: Dreijerink, Koen Marie Anton, et al.
Publicado: (2022)

Diagnostic Utility of Menin Immunohistochemistry in Patients With Multiple Endocrine Neoplasia Type 1 Syndrome
por: Verschuur, Anna Vera D., et al.
Publicado: (2023)

Genome-Wide Analysis of Menin Binding Provides Insights into MEN1 Tumorigenesis
por: Scacheri, Peter C, et al.
Publicado: (2006)

Overexpression, purification and preliminary X-ray diffraction analysis of the controller protein C.Csp231I from Citrobacter sp. RFL231
por: Streeter, S. D., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_2rk7j1e40ug7sqtu3ff9vhh5if