Microglia use TAM receptors to detect and engulf amyloid beta plaques

Two microglial TAM receptor tyrosine kinases - Axl and Mer - have been linked to Alzheimer’s disease, but their roles in disease have not been tested experimentally. We find that in Alzheimer’s disease and its mouse models, induced expression of Axl and Mer in amyloid plaque-associated microglia was...

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Detalles Bibliográficos
Autores principales: Huang, Youtong, Happonen, Kaisa E., Burrola, Patrick G., O’Connor, Carolyn, Hah, Nasun, Huang, Ling, Nimmerjahn, Axel, Lemke, Greg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102389/
https://www.ncbi.nlm.nih.gov/pubmed/33859405
http://dx.doi.org/10.1038/s41590-021-00913-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102389/
https://www.ncbi.nlm.nih.gov/pubmed/33859405
http://dx.doi.org/10.1038/s41590-021-00913-5

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