Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism

Overexpression and aggregation of α-synuclein (ASyn) are linked to the onset and pathology of Parkinson’s disease and related synucleinopathies. Elevated levels of the stress-induced chaperone Hsp70 protect against ASyn misfolding and ASyn-driven neurodegeneration in cell and animal models, yet ther...

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Detalles Bibliográficos
Autores principales: Tao, Jiahui, Berthet, Amandine, Citron, Y. Rose, Tsiolaki, Paraskevi L., Stanley, Robert, Gestwicki, Jason E., Agard, David A., McConlogue, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102405/
https://www.ncbi.nlm.nih.gov/pubmed/33798554
http://dx.doi.org/10.1016/j.jbc.2021.100613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102405/
https://www.ncbi.nlm.nih.gov/pubmed/33798554
http://dx.doi.org/10.1016/j.jbc.2021.100613

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