Coordinate regulation of systemic and kidney tryptophan metabolism by the drug transporters OAT1 and OAT3

How organs sense circulating metabolites is a key question. Here, we show that the multispecific organic anion transporters of drugs, OAT1 (SLC22A6 or NKT) and OAT3 (SLC22A8), play a role in organ sensing. Metabolomics analyses of the serum of Oat1 and Oat3 knockout mice revealed changes in tryptoph...

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Detalles Bibliográficos
Autores principales: Granados, Jeffry C., Richelle, Anne, Gutierrez, Jahir M., Zhang, Patrick, Zhang, Xinlian, Bhatnagar, Vibha, Lewis, Nathan E., Nigam, Sanjay K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102410/
https://www.ncbi.nlm.nih.gov/pubmed/33757768
http://dx.doi.org/10.1016/j.jbc.2021.100575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102410/
https://www.ncbi.nlm.nih.gov/pubmed/33757768
http://dx.doi.org/10.1016/j.jbc.2021.100575

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