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Coordinate regulation of systemic and kidney tryptophan metabolism by the drug transporters OAT1 and OAT3

How organs sense circulating metabolites is a key question. Here, we show that the multispecific organic anion transporters of drugs, OAT1 (SLC22A6 or NKT) and OAT3 (SLC22A8), play a role in organ sensing. Metabolomics analyses of the serum of Oat1 and Oat3 knockout mice revealed changes in tryptoph...

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Detalles Bibliográficos
Autores principales:	Granados, Jeffry C., Richelle, Anne, Gutierrez, Jahir M., Zhang, Patrick, Zhang, Xinlian, Bhatnagar, Vibha, Lewis, Nathan E., Nigam, Sanjay K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102410/ https://www.ncbi.nlm.nih.gov/pubmed/33757768 http://dx.doi.org/10.1016/j.jbc.2021.100575

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