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pH induced conformational alteration in human peroxiredoxin 6 might be responsible for its resistance against lysosomal pH or high temperature

Peroxiredoxin 6 (Prdx6), the ubiquitously expressed enzyme belonging to the family of peroxidases, namely, peroxiredoxins, exhibits a unique feature of functional compartmentalization within cells. Whereas, the enzyme localized in cytosol shows glutathione peroxidase activity, its lysosomal counterp...

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Detalles Bibliográficos
Autores principales: Chowhan, Rimpy Kaur, Hotumalani, Sunaina, Rahaman, Hamidur, Singh, Laishram Rajendrakumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102515/
https://www.ncbi.nlm.nih.gov/pubmed/33958651
http://dx.doi.org/10.1038/s41598-021-89093-8