Ibudilast (MN-166) in amyotrophic lateral sclerosis- an open label, safety and pharmacodynamic trial

Ibudilast (MN-166) is an inhibitor of macrophage migration inhibitory factor (MIF) and phosphodiesterases 3,4,10 and 11 (Gibson et al., 2006; Cho et al., 2010). Ibudilast attenuates CNS microglial activation and secretion of pro-inflammatory cytokines (Fujimoto et al., 1999; Cho et al., 2010). In vi...

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Detalles Bibliográficos
Autores principales: Babu, Suma, Hightower, Baileigh G., Chan, James, Zürcher, Nicole R., Kivisäkk, Pia, Tseng, Chieh-En J., Sanders, Danica L., Robichaud, Ashley, Banno, Haruhiko, Evora, Armineuza, Ashokkumar, Akshata, Pothier, Lindsay, Paganoni, Sabrina, Chew, Sheena, Dojillo, Joanna, Matsuda, Kazuko, Gudesblatt, Mark, Berry, James D., Cudkowicz, Merit E., Hooker, Jacob M, Atassi, Nazem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102622/
https://www.ncbi.nlm.nih.gov/pubmed/34016561
http://dx.doi.org/10.1016/j.nicl.2021.102672

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102622/
https://www.ncbi.nlm.nih.gov/pubmed/34016561
http://dx.doi.org/10.1016/j.nicl.2021.102672

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