Inhibition of AKT/GSK3β/CREB Pathway Improves the Responsiveness to AMPA Receptor Antagonists by Regulating GRIA1 Surface Expression in Chronic Epilepsy Rats

α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPAR) has been reported as one of the targets for treatment of epilepsy. Although maladaptive regulation of surface expression of glutamate ionotropic receptor AMPA type subunit 1 (GRIA1) subunit is relevant to the responsiveness to AMP...

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Detalles Bibliográficos
Autores principales: Kim, Ji-Eun, Lee, Duk-Shin, Park, Hana, Kim, Tae-Hyun, Kang, Tae-Cheon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103519/
https://www.ncbi.nlm.nih.gov/pubmed/33919872
http://dx.doi.org/10.3390/biomedicines9040425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103519/
https://www.ncbi.nlm.nih.gov/pubmed/33919872
http://dx.doi.org/10.3390/biomedicines9040425

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