Reduced Nucleoprotein Availability Impairs Negative-Sense RNA Virus Replication and Promotes Host Recognition

Negative-sense RNA viruses (NSVs) rely on prepackaged viral RNA-dependent RNA polymerases (RdRp) to replicate and transcribe their viral genomes. Their replication machinery consists of an RdRp bound to viral RNA which is wound around a nucleoprotein (NP) scaffold, forming a viral ribonucleoprotein...

Descripción completa

Detalles Bibliográficos
Autores principales: Nilsson-Payant, Benjamin E., Blanco-Melo, Daniel, Uhl, Skyler, Escudero-Pérez, Beatriz, Olschewski, Silke, Thibault, Patricia, Panis, Maryline, Rosenthal, Maria, Muñoz-Fontela, César, Lee, Benhur, tenOever, Benjamin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Cellular Response to Infection
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104106/
https://www.ncbi.nlm.nih.gov/pubmed/33568513
http://dx.doi.org/10.1128/JVI.02274-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104106/
https://www.ncbi.nlm.nih.gov/pubmed/33568513
http://dx.doi.org/10.1128/JVI.02274-20

Ejemplares similares