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Discovery of a Novel Specific Inhibitor Targeting Influenza A Virus Nucleoprotein with Pleiotropic Inhibitory Effects on Various Steps of the Viral Life Cycle

Influenza A viruses (IAVs) continue to pose an imminent threat to humans due to annual influenza epidemic outbreaks and episodic pandemics with high mortality rates. In this context, the suboptimal vaccine coverage and efficacy, coupled with recurrent events of viral resistance against a very limite...

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Detalles Bibliográficos
Autores principales: Yang, Fang, Pang, Bo, Lai, Kin Kui, Cheung, Nam Nam, Dai, Jun, Zhang, Weizhe, Zhang, Jinxia, Chan, Kwok-Hung, Chen, Honglin, Sze, Kong-Hung, Zhang, Hongmin, Hao, Quan, Yang, Dan, Yuen, Kwok-Yung, Kao, Richard Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104107/
https://www.ncbi.nlm.nih.gov/pubmed/33627391
http://dx.doi.org/10.1128/JVI.01432-20